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keto seafood casserole made in a pie pan

Easy Keto Seafood Casserole

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5 from 1 review

A creamy, quick, and easy Keto Seafood Casserole is the perfect weeknight meal since this keto recipe uses frozen seafood.  A savory blend of seafood and rich cheeses bakes in this delicious pie that’s hearty enough to satisfy even the hungriest of crews. Serve for dinner, lunch, or brunch!

  • Total Time: 45 minutes
  • Yield: 8 slices 1x


Units Scale
  • 16 oz (1 pound) frozen mixed seafood, thawed and drained or frozen salad shrimp, thawed and drained
  • 2 cups shredded sharp natural Cheddar cheese (or Swiss, Havarti or a combination), divided
  • 8 oz sliced mushrooms
  • 1/2 onion, diced
  • 1 cup Keto Bisquick mix
  • 1/4 cup unsalted butter, melted
  • 1/4-1/2 tsp salt *
  • 1/2 tsp nutmeg
  • 4 eggs


  1. Preheat the oven to 350 degrees F.  Grease a pie pan (or another baking dish) and place it on a rimmed baking sheet.  Set it to the side.
  2. In a large bowl, combine the keto Bisquick, melted butter, salt, nutmeg, and eggs and whisk until combined.  Add 1 cup of cheese and stir to combine.  Set the bowl to the side.
  3. In a large skillet sprayed with cooking oil, add the onion and mushrooms.  Cook on medium-high heat until they begin to brown, about 5 minutes.  Add in the thawed and drained seafood and cook, stirring constantly, for about 1-2 minutes or until the seafood starts to turn opaque.  Remove the skillet from the heat.
  4. Add the mushroom/onion/seafood mixture to the Bisquick/egg bowl and stir to incorporate.  Add 3/4 cup of cheese to the mixture.
  5. Carefully pour the mixture into the pie pan and sprinkle with the remaining 1/4 cup of cheese.  Bake on the middle rack for about 30-40 minutes or until the top begins to brown and the center is set.
  6. Remove from the oven and allow it to cool slightly for 10 minutes before serving.


  • *I do not like to add too much salt to my recipes as you can always add more after serving but you can not remove it!  So, if you use a saltier cheese, only use 1/4 teaspoon but if you use a cheese like mozzarella which is not as salty, feel free to use 1/2 teaspoon.
  • Baking time varies due to the type of pan you use
  • see post for keto Bisquick substitution
  • Author: Cat
  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Category: Breakfast, Brunch, Dinner, Lunch
  • Method: Baking
  • Cuisine: American, Seafood, Casserole
  • Diet: Gluten Free


  • Serving Size: 1 slice
  • Calories: 250
  • Sugar: 1
  • Fat: 18
  • Carbohydrates: 3
  • Fiber: 0.5
  • Protein: 18
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